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Preventing the Development of Peanut Allergy

Update – Preventing the Development of Peanut Allergy – Clinical Guidelines in Early Introduction of Peanut-Containing Foods to Infants have been issued by an expert panel sponsored by the NIH National Institute of Allergy and Infectious Diseases (NIAID) which notes that “… recent scientific research has demonstrated that introducing peanut-containing foods into the diet during infancy can prevent the development of peanut allergy …” – The new Addendum Guidelines for the Prevention of Peanut Allergy in the United States “… supplement the 2010 Guidelines for the Diagnosis and Management of Food Allergy in the United States [and] provide three separate guidelines for infants at various levels of risk for developing peanut allergy … In all cases, infants should start other solid foods before they are introduced to peanut-containing foods …”

Document Title: * The title of the January 5, 2017 NIH NIAID News Release is “NIH-sponsored expert panel issues clinical guidelines to prevent peanut allergy; Recommendations focus on introducing peanut-containing foods to infants”
* The title of the June 10, 2016 NIH NIAID News Release is “Peanut Allergy Prevention Strategy Is Nutritionally Safe, NIH-Funded Study Shows; Early-Life Peanut Consumption Does Not Affect Duration of Breastfeeding or Children’s Growth and Nutrition”
* The title of the March 4, 2016 NIH NIAID News Release is “Benefits of peanut allergy prevention strategy persist after one-year peanut avoidance; NIH-funded study suggests early peanut consumption will offer lasting protection”

Organization: NIH NIAID Press Office

Source: January 5, 2017, June 10, 2016 and March 4, 2016 NIH News Releases

Web site: The January 5, 2017 NIH News Release is posted at
http://www.nih.gov/news-events/news-releases/nih-sponsored-expert-panel-issues-clinical-guidelines-prevent-peanut-allergy

The 2017 Addendum Guidelines for the Prevention of Peanut Allergy in the United States are posted at
http://www.niaid.nih.gov/diseases-conditions/guidelines-clinicians-and-patients-food-allergy
* Specifically at
http://www.jacionline.org/article/S0091-6749(16)31222-2/fulltext
* An Addendum Summary for Clinicians is posted at
https://www.niaid.nih.gov/sites/default/files/peanut-allergy-prevention-guidelines-clinician-summary.pdf

* An Addendum Summary for Parents and Caregivers is posted at
http://www.niaid.nih.gov/sites/default/files/peanut-allergy-prevention-guidelines-parent-summary.pdf

The June 10, 2016 NIH News Release is posted at
http://www.nih.gov/news-events/news-releases/peanut-allergy-prevention-strategy-nutritionally-safe-nih-funded-study-shows

The June 10, 2016 article in the Journal of Allergy and Clinical Immunology, titled “Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition”, is posted at
http://www.jacionline.org/article/S0091-6749%2816%2930262-7/abstract

The March 4, 2016 NIH News Release is posted at
http://www.nih.gov/news-events/news-releases/benefits-peanut-allergy-prevention-strategy-persist-after-one-year-peanut-avoidance

The March 4, 2016 article in the New England Journal of Medicine, titled “Effect of Avoidance on Peanut Allergy after Early Peanut Consumption”, is posted at
http://www.nejm.org/doi/full/10.1056/NEJMoa1514209

Additional information about the Learning Early About Peanut Allergy (LEAP) clinical trial is available at
http://www.leapstudy.co.uk/

The previous FIEN message related to this topic is posted at
http://www.fien.com/articleDisplay.php?id=37302

Summary: The text of the January 5, 2017 NIH News Release follows:

An expert panel sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, issued clinical guidelines today to aid health care providers in early introduction of peanut-containing foods to infants to prevent the development of peanut allergy.

Peanut allergy is a growing health problem for which no treatment or cure exists. People living with peanut allergy, and their caregivers, must be vigilant about the foods they eat and the environments they enter to avoid allergic reactions, which can be severe and even life-threatening. The allergy tends to develop in childhood and persist through adulthood. However, recent scientific research has demonstrated that introducing peanut-containing foods into the diet during infancy can prevent the development of peanut allergy.

The new Addendum Guidelines for the Prevention of Peanut Allergy in the United States supplement the 2010 Guidelines for the Diagnosis and Management of Food Allergy in the United States (http://www.jacionline.org/article/S0091-6749%2810%2901566-6/fulltext ). The addendum provides three separate guidelines for infants at various levels of risk for developing peanut allergy and is targeted to a wide variety of health care providers, including pediatricians and family practice physicians.

“Living with peanut allergy requires constant vigilance. Preventing the development of peanut allergy will improve and save lives and lower health care costs,” said NIAID Director Anthony S. Fauci, M.D. “We expect that widespread implementation of these guidelines by health care providers will prevent the development of peanut allergy in many susceptible children and ultimately reduce the prevalence of peanut allergy in the United States.”

Addendum Guideline 1 focuses on infants deemed at high risk of developing peanut allergy because they already have severe eczema, egg allergy or both. The expert panel recommends that these infants have peanut-containing foods introduced into their diets as early as 4 to 6 months of age to reduce the risk of developing peanut allergy. Parents and caregivers should check with their infant’s health care provider before feeding the infant peanut-containing foods. The health care provider may choose to perform an allergy blood test or send the infant to a specialist for other tests, such as a skin prick test or an oral food challenge. The results of these tests will help decide if and how peanut should be safely introduced into the infant’s diet.

Guideline 2 suggests that infants with mild or moderate eczema should have peanut-containing foods introduced into their diets around 6 months of age to reduce the risk of peanut allergy. Guideline 3 suggests that infants without eczema or any food allergy have peanut-containing foods freely introduced into their diets.

In all cases, infants should start other solid foods before they are introduced to peanut-containing foods.

Development of the Addendum Guidelines was prompted by emerging data suggesting that peanut allergy can be prevented by the early introduction of peanut-containing foods. Clinical trial results reported in February 2015 (http://www.nih.gov/news-events/news-releases/study-finds-peanut-consumption-infancy-prevents-peanut-allergy ) showed that regular peanut consumption begun in infancy and continued until 5 years of age led to an 81 percent reduction in development of peanut allergy in infants deemed at high risk because they already had severe eczema, egg allergy or both. This finding came from the landmark, NIAID-funded Learning Early About Peanut Allergy (http://www.leapstudy.co.uk/ ) (LEAP) study, a randomized clinical trial involving more than 600 infants.

“The LEAP study clearly showed that introduction of peanut early in life significantly lowered the risk of developing peanut allergy by age 5. The magnitude of the benefit and the scientific strength of the study raised the need to operationalize these findings by developing clinical recommendations focused on peanut allergy prevention,” said Daniel Rotrosen, M.D., director of NIAID’s Division of Allergy, Immunology and Transplantation.

In 2015, NIAID established a coordinating committee representing 26 professional organizations, advocacy groups and federal agencies to oversee development of the Addendum Guidelines to specifically address the prevention of peanut allergy. The coordinating committee convened a 26-member expert panel comprising specialists from a variety of relevant clinical, scientific and public health areas. The panel, chaired by Joshua Boyce, M.D., professor of medicine and pediatrics at Harvard Medical School, used a literature review of food allergy prevention research and their own expert opinions to prepare draft guidelines. The draft guidelines were available on the NIAID website for public comment from March 4 to April 18, 2016. The expert panel and coordinating committee reviewed the 104 comments received to develop the final Addendum Guidelines.

The Addendum Guidelines appear January 5 in the Journal of Allergy and Clinical Immunology and will be co-published in the Annals of Allergy, Asthma, and Immunology; Journal of Pediatric Nursing; Pediatric Dermatology; World Allergy Organization Journal; and Allergy, Asthma, and Clinical Immunology. Related resources, including a Summary for Clinicians (http://www.niaid.nih.gov/sites/default/files/peanut-allergy-prevention-guidelines-clinician-summary.pdf ) and Summary for Parents and Caregivers (http://www.niaid.nih.gov/sites/default/files/peanut-allergy-prevention-guidelines-parent-summary.pdf ), are freely accessible on the NIAID food allergy guidelines webpage (http://www.niaid.nih.gov/diseases-conditions/guidelines-clinicians-and-patients-food-allergy ). A PDF copy of the Addendum Guidelines also will be made available there soon.

NIAID conducts and supports research — at NIH, throughout the United States, and worldwide — to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website (http://www.niaid.nih.gov/ ).

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov .

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